Johannes Gutenberg Universität   Institut für Anthropologie   Deutsch








 
SYNTHESYS
 
 Joachim Burger,  Christian Sell,  Melanie Strobel
 
Co-Worker:    Ian Barnes,  Matthew Collins
 
 
"This study is funded by SYNTHESYS: the European Union-funded Integrated Activities grant. SYNTHESYS aims to produce an accessible, integrated European resource for research users in the natural sciences. SYNTHESYS will create a shared, high quality approach to the management, preservation, and access to leading European natural history collections. Alongside the Access, a Joint Research Activity (JRA) will deliver new tools to enable users to more efficiently gain DNA from valuable archive material. The rapid and extensive development of Next-Generation sequencing technologies (NGS) has a great impact on ancient DNA research. The amount of data that can be generated with such methods has increased drastically in comparison to classic Sanger sequencing. To apply such new technologies, operating processes in molecular genetics and bioinformatics have to be adapted to the special needs of prehistoric materials. Our group aims at creating a protocol for both, DNA libraries for museum specimens and soil embedded archaeological remains of any organism of interest. By doing so the genetic information contained in a DNA library could virtually immortalize the organism and be used for further studies like population genetics or phylogenetic analysis. To achieve this we have focused our research on:
 
 
  1. Optimizing an Illumina Library generation protocol for very small amounts of highly degraded ancient DNA (aDNA).

  2. Reducing the amount of contaminating DNA introduced by fungi or microorganisms.

  3. Targeted enrichment of endogenous DNA.



Partner:
  • Natural History Museum, London (NHM) (Project Coordinator), UK
  • Naturhistorisches Museum, Wien (NHMW), Austria
  • Royal Belgian Institute of Natural Sciences, Brussels (RBINS), Belgium
  • Royal Museum for Central Africa, Tervuren (RMCA), Belgium
  • The University of Copenhagen, Copenhagen (UCPH), Denmark
  • useum National d’Histoire Naturelle, Paris (MNHN), France
  • Botanic Garden and Botanical Museum Berlin-Dahlem, Berlin (BGBM), Germany
  • Johannes Gutenberg-University, Mainz (Mainz), Germany
  • Museum für Naturkunde, Berlin (MfN), Germany
  • Hungarian Natural History Museum, Budapest (HNHM), Hungary
  • National Museum of Natural History Naturalis, Leiden (NNM), Netherlands
  • Nationaal Herbarium Nederland, Leiden (NHN), Netherlands
  • Zoological Museum of the University of Amsterdam, Amsterdam (UvA), Netherlands
  • Consejo Superior de Investigaciones Científicas, Madrid (CSIC), Spain
  • The Swedish Museum of Natural History, Stockholm (NRM), Sweden
  • Royal Botanic Gardens Kew, London (RBGK), UK
  • Royal Botanic Garden Edinburgh, Edinburgh (RBGE), UK
  • Royal Holloway University London, London (RHUL), UK
  • York University, York (York), UK
 
 
 
 








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