|
Mitarbeiter
Tobias Bopp,
Gruppenleiter
|
|
|
Today it is widely accepted that naturally occurring CD4+CD25+ regulatory T cells (Tregs) are essential
to prevent the induction of autoimmune diseases by inhibiting the activation of self-reactive T cells.
However, the underlying molecular mechanisms of this cell contact-dependent process are still elusive.
The main focus of my research is to further characterize the signaling pathways involved in the suppression
of CD4+ T cells by Tregs. In particular, I am working with mice that are double-deficient in the transcription
factors NFATc2 and NFATc3. Furthermore, we are employing genetic approaches including siRNA, reporter gene
strategies ,and other common methods of molecular biology as well as common methods of cellular immunology
to further understand the mechansims of Treg-mediated suppression.
|
|
