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Ausgesuchte Veröffentlichungen
2007 |2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000
2007 (Zurück zur Übersicht)
Reineke J, Tenzer S, Rupnik M, Koschinski A, Hasselmayer O, Schrattenholz A, Schild H, von Eichel-Streiber C. Autocatalytic cleavage of Clostridium difficile toxin B.
Nature. 2007;446(7134):415-9. PMID: 17334356
Bopp T, Becker C, Klein M, Klein-Hessling S, Palmetshofer A, Serfling E, Heib V, Becker M, Kubach J, Schmitt S, Stoll S, Schild H, Staege MS, Stassen M, Jonuleit H, Schmitt E. Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J Exp Med. 2007;204(6):1303-10. PMID: 17502663
Heib V, Becker M, Warger T, Rechtsteiner G, Tertilt C, Klein M, Bopp T, Taube C, Schild H, Schmitt E, Stassen M. Mast cells are crucial for early inflammation, migration of Langerhans cells and CTL responses following topical application of TLR7 ligand in mice. Blood. 2007 Apr 19; [Epub ahead of print] PMID: 17446350
Haselmayer P, Grosse-Hovest L, Landenberg PV, Schild H, Radsak MP. TREM-1 ligand expression on platelets enhances neutrophil activation. Blood. 2007 Apr 23; [Epub ahead of print] PMID: 17452516
Graf C, Heidel F, Tenzer S, Radsak MP, Solem FK, Britten CM, Huber C, Fischer T, Wolfel T. A neoepitope generated by an FLT3 internal tandem duplication (FLT3-ITD) is recognized by leukemia-reactive autologous CD8+ T cells. Blood. 2007;109(7):2985-8.
PMID: 17119119
Kubach J, Lutter P, Bopp T, Stoll S, Becker C, Huter E, Richter C, Weingarten P, Warger T, Knop J, Mullner S, Wijdenes J, Schild H, Schmitt E, Jonuleit H. Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function. Blood. 2007 May 14; [Epub ahead of print]
PMID: 17502455
Stassen M, Klein M, Becker M, Bopp T, Neudorfl C, Richter C, Heib V, Klein-Hessling S, Serfling E, Schild H, Schmitt E. p38 MAP kinase drives the expression of mast cell-derived IL-9 via activation of the transcription factor GATA-1.
Mol Immunol. 2007;44(5):926-33. PMID: 16650898
Warger T, Rechtsteiner G, Schmid B, Osterloh P, Schild H, Radsak MP. Transcutaneous Immunization With Imiquimod Is Amplified by CD40 Ligation and Results in Sustained Cytotoxic T-Lymphocyte Activation and Tumor Protection. Clin Rev Allergy Immunol. 2007;32(1):57-66. PMID: 17426361
Warger T, Schild H, Rechtsteiner G. Initiation of adaptive immune responses by transcutaneous immunization. Immunol Lett. 2007;109(1):13-20. PMID: 17320194
2006 (Zurück zur Übersicht)
Klein M, Klein-Hessling S, Palmetshofer A, Serfling E, Tertilt C, Bopp T, Heib V, Becker M, Taube C, Schild H, Schmitt E, Stassen M. Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines.
J Immunol. 2006;177(10):6667-74. PMID: 17082579
Serfling E, Klein-Hessling S, Palmetshofer A, Bopp T, Stassen M, Schmitt E.
NFAT transcription factors in control of peripheral T cell tolerance. Eur J Immunol. 2006;36(11):2837-43. Review. PMID: 17039563
Stassen M, Valeva A, Walev I, Schmitt E. Activation of mast cells by streptolysin O and lipopolysaccharide. Methods Mol Biol. 2006;315:393-403. PMID: 16110172
Asemissen AM, Keilholz U, Tenzer S, Muller M, Walter S, Stevanovic S, Schild H, Letsch A, Thiel E, Rammensee HG, Scheibenbogen C. Identification of a highly immunogenic HLA-A*01-binding T cell epitope of WT1. Clin Cancer Res. 2006;12(24):7476-82. PMID: 17189421
Haselmayer P, Tenzer S, Kwon BS, Jung G, Schild H, Radsak MP. Herpes virus entry mediator synergizes with Toll-like receptor mediated neutrophil inflammatory responses.
Immunology. 2006;119(3):404-11.PMID: 17067315
Rechtsteiner G, Warger T, Hofmann M, Rammensee HG, Schild H, Radsak MP. Precursor frequency can compensate for lower TCR expression in T cell competition during priming in vivo. Eur J Immunol. 2006;36(10):2613-23. PMID: 16955523
Wirtz S, Tubbe I, Galle PR, Schild HJ, Birkenbach M, Blumberg RS, Neurath MF. Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27. J Exp Med. 2006;203(8):1875-81. PMID: 16880260
Warger T, Hilf N, Rechtsteiner G, Haselmayer P, Carrick DM, Jonuleit H, von Landenberg P, Rammensee HG, Nicchitta CV, Radsak MP, Schild H. Interaction of TLR2 and TLR4 ligands with the N-terminal domain of Gp96 amplifies innate and adaptive immune responses. J Biol Chem. 2006;281(32):22545-53. PMID: 16754684
Osterloh P, Linkemann K, Tenzer S, Rammensee HG, Radsak MP, Busch DH, Schild H. Proteasomes shape the repertoire of T cells participating in antigen-specific immune responses. Proc Natl Acad Sci U S A. 2006;103(13):5042-7. PMID: 16549793
Warger T, Osterloh P, Rechtsteiner G, Fassbender M, Heib V, Schmid B, Schmitt E, Schild H, Radsak MP. Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo. Blood. 2006;108(2):544-50. PMID: 16537810
Bruder D, Nussbaum AK, Gakamsky DM, Schirle M, Stevanovic S, Singh-Jasuja H, Darji A, Chakraborty T, Schild H, Pecht I, Weiss S. Multiple synergizing factors contribute to the strength of the CD8+ T cell response against listeriolysin O. Int Immunol. 2006;18(1):89-100. PMID: 16291651
2005 (Zurück zur Übersicht)
Ramirez, S., Singh-Jasuja, H., Warger, T., Braedel-Ruoff, S., Hilf, N., Wiemann, K., Rammensee, H.-G., and H. Schild. Glykoprotein 96-activated dendritic cells induce a CD8-biased T cell reponse. 2005. Cell Stress & Chaperones. 10:221-9
Herter, S., Hilf, N., Osterloh, P., Rechtsteiner, G., Höhfeld, J., Rammensee, H-G., and H. Schild. 2005. DALIS formation coincides with antigen presentation in influenza virus infected dendritic cells. J. Immunol. 175:891-8
Rechtsteiner, G., Warger, T., Osterloh, P., Schild, H.*, and M. P. Radsak*. Priming of cytotoxic T lymphocytes by transcutaneus peptide immunization with imiquimod. 2005. J. Immunol. Cutting Edge 174:2476-80 * joint senior authors
Bopp, T., Palmetshofer, A., Serfling, E., Heib, V., Schmitt, S., Richter, C., Klein, M., Schild, H., Schmitt, E.*, and Stassen, M.*. 2005. NFATc2 and c3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by regulatory T cells. J. Exp. Med. 201:181 * joint senior authors
Tenzer, S., Peters, B., Bulik, S., Schoor, O., Lemmel, C., Schatz, M.M., Kloetzel, P.-M., Rammensee, H.-G., Schild, H.* and H.-G. Holzhütter. 2005. Modeling the MHC class-I pathway by combining predictions of proteasomal cleavage, TAP transport and MHC class-I binding. Cell. Mol. Life. Sci. 62:1025-1037 * corresponding author
Wirtz, S., Becker, C., Fantini, M.C., Nieuwenhuis, E.E., Tubbe, I., Galle, P.R., Schild, H., Birkenbach, M., Blumberg, R.S., and M. Neurath. 2005. EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappaB activation. J. Immunol. 174:2814-24
Tenzer, S. and H. Schild. Assays of proteasome-dependent cleavage products. 2005. Methods Mol. Biol. 301:97-115
Braedel, S., Faigle, M., Hilf, N., Neumeister, B., and H. Schild. 2005. Legionella pneumophila activation of dendritic cells involves CD14 and TLR2. J. Endotoxin Research, 11:89-96
Schild, H., Jonuleit, H., Schmitt, E., and J. Knop. Dendritic Cell-Based Immunotherapy of Cancer: Limited by Regulatory T Cells and Amplified by TLR-Ligand Stimulation. 2005. Recent Research Developments in Cancer, In press
2004 (Zurück zur Übersicht)
Norbert Hilf, Markus Radsak, Hansjörg Schild. Host-derived Adjuvants. In Novel Vaccination Strategies by Stefan Kaufmann Wiley-VCH ,2004
Stassen, M., Fondel, S., Bopp, T., Richter, C., Müller, C., Knop, J., Enk, A.H., Schmitt, S., Schmitt, E*, and Jonuleit, H*. 2004. Human CD25+ regulatory T cells: Two subsets defined by the integrins ?4?7 or ?4?1, confer distinct suppressive properties upon CD4+ T helper cells. Eur. J. Immunol. May;34(5):1303-11 * Joint senior authors
Matthias Hofmann, Markus Radsak, Gerd Rechtsteiner, Katrin Wiemann, Marc Günder, Ursula Bien-Gräter, Rienk Offringa, René E.M. Toes, Hans-Georg Rammensee, Hansjörg Schild. T cell avidity determines the level of CTL activation. European Journal of Immunology 2004;34: 1798-1806
Tenzer S, Stoltze L, Schonfisch B, Dengjel J, Muller M, Stevanovic S, Rammensee HG, Schild H. Quantitative analysis of prion-protein degradation by constitutive and immuno-20S proteasomes indicates differences correlated with disease susceptibility. J Immunol. 2004 Jan 15;172(2):1083-91.
Markus P. Radsak, Helmut R. Salih, Hans-Georg Rammensee, Hansjörg Schild. TREM-1 in neutrophil inflammatory responses: Differential regulation of activation and survival. Journal of Immunology 2004;172:4956-4963
Radsak MP, Salih HR, Rammensee HG, Schild H. Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival. J Immunol. 2004 Apr 15;172(8):4956-63.
Stassen, M., Jonuleit, H., Müller, C., Klein, M., Richter, C., Bopp, T., Schmitt, S., and Schmitt, E. 2004. Differential regulatory capacity of CD25+ Treg cells and preactivated CD25+ Treg cells on development, functional activation and proliferation of Th2 cells. J. Immunol. Jul 1;173(1):267-74.
Tenzer S and Schild H. Assays of proteasome-dependent cleavage products. Methods in Molecular Biology, Humana Press, 2004
2003 (Zurück zur Übersicht)
Nussbaum AK, Kuttler C, Tenzer S, Schild H. Using the World Wide Web for predicting CTL epitopes. Curr Opin Immunol. 2003 Feb;15(1):69-74.
Stassen, M., Müller, M., Richter, C., Neudörfl, C., Hültner, L., Bhakdi, S., Walev, I., and Schmitt, E. 2003. The streptococcal exotoxin streptolysin O activates mast cells to produce TNF-? by p38 MAP-kinase-and protein kinase C-dependent pathways. Infect. Immmunity. Nov;71(11):6171-77
2002 (Zurück zur Übersicht)
Vabulas RM, Braedel S, Hilf N, Singh-Jasuja H, Herter S, Ahmad-Nejad P, Kirschning CJ, Da Costa C, Rammensee HG, Wagner H, Schild H. The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway. J Biol Chem. 2002 Jun 7;277(23):20847-53. Epub 2002 Mar 23.
Hilf N, Singh-Jasuja H, Schild H. The heat shock protein Gp96 links innate and specific immunity. Int J Hyperthermia. 2002 Nov-Dec;18(6):521-33.
Jonuleit, H., Schmitt, E., Kakirman, H., Stassen, M., Knop, J., and Enk, A.H. 2002. Infectious tolerance: Human CD25+ regulatory T cells convey suppressor activity to conventional CD4+ T helper cells. J. Exp. Med.196(2):255-60.
Radsak MP, Hilf N, Singh-Jasuja H, Braedel S, Brossart P, Rammensee HG, Schild H. The heat shock protein Gp96 binds to human neutrophils and monocytes and stimulates effector functions. Blood. 2003;101:2810-5
2001 (Zurück zur Übersicht)
Singh-Jasuja H, Hilf N, Arnold-Schild D, Schild H. The role of heat shock proteins and their receptors in the activation of the immune system. Biol Chem. 2001 Apr;382(4):629-36.
Hofmann M, Nussbaum AK, Emmerich NP, Stoltze L, Schild H. Mechanisms of MHC class I-restricted antigen presentation.Expert Opin Ther Targets. 2001 Jun;5(3):379-393.
Stassen, M., Müller, C., Arnold, M., Hültner, L., Klein-Heßling, S., Neudörfl, C., Reineke, T., Serfling, E., and Schmitt, E. 2001. IL-9 and IL-13 production by activated mast cells is strongly enhanced in the presence of LPS: NF-*B is decisively involved in the expression of IL-9. J. Immunol. 166: 4391-4398.
Toes RE, Nussbaum AK, Degermann S, Schirle M, Emmerich NP, Kraft M, Laplace C, Zwinderman A, Dick TP, Muller J, Schonfisch B, Schmid C, Fehling HJ, Stevanovic S, Rammensee HG, Schild H. Discrete cleavage motifs of constitutive and immunoproteasomes revealed by quantitative analysis of cleavage products. J Exp Med. 2001 Jul 2;194(1):1-12.
Nussbaum AK, Kuttler C, Hadeler KP, Rammensee HG, Schild H. PAProC: a prediction algorithm for proteasomal cleavages available on the WWW. Immunogenetics. 2001 Mar;53(2):87-94.
Jonuleit, H., Schmitt, E., Stassen, M., Tuettenberg, A., Knop, J., and Enk, A. H. 2001. Identification and functional characterization of human CD4+CD25+ T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. 193:1285-1294.
2000 (Zurück zur Übersicht)
Schild H, Rammensee HG. gp96--the immune system's Swiss army knife. Nat Immunol. 2000 Aug;1(2):100-1.
Singh-Jasuja H, Toes RE, Spee P, Munz C, Hilf N, Schoenberger SP, Ricciardi-Castagnoli P,# Neefjes J, Rammensee HG, Arnold-Schild D, Schild H. Cross-presentation of glycoprotein 96-associated antigens on major histocompatibility complex class I molecules requires receptor-mediated endocytosis.J Exp Med. 2000 Jun 5;191(11):1965-74.
Stassen, M., Arnold, M., Hültner, L., Müller, C., Neudörfl, C., and Schmitt, E. 2000. Murine bone marrow-derived mast cells as potent producers of IL-9: Costimulatory function of IL-10 and kit-ligand in the presence of IL-1. J. Immunol. 164:5549-5555
Stoltze L, Schirle M, Schwarz G, Schroter C, Thompson MW, Hersh LB, Kalbacher H, Stevanovic S, Rammensee HG, Schild H. Two new proteases in the MHC class I processing pathway. Nat Immunol. 2000 Nov;1(5):413-8.
Jonuleit*, H., Schmitt*, E., Schuler, G., Knop, J., and Enk, A.H. 2000. Induction of human IL-10-producing, non-proliferating CD4+ T-cells with regulatory properties by repetitive stimulation with allogeneic immature dendritic cells. J. Exp. Med. 192:1213-1222 *) contributed equally to this work
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