Structure

Hansjörg Schild, Ph.D.
Chairman

Institute of Immunology
Johannes Gutenberg-University
Obere Zahlbacher Strasse 67
55131 Mainz

Portrait Schild

Career history

Prof. Schild graduated in Human Biology from the University of Marburg in 1989. He performed his PhD work at the Basel Institute of Immunology and the Max-Planck Institute for Biology, Dept. of Immunogenetics in Tübingen. From 1990 to 1993 he was a Postdoctoral Fellow at the Stanford University Medical School. For the next three years he was group leader of the Department of Tumorvirus-Immunology of the German Cancer Research Center in Heidelberg, Germany. From 1996 to 2003 he was group leader at the Department of Immunology, Institute for Cell Biology and academic teacher at the University of Tübingen, Germany. Since 2005 he also chairs together with Prof. Huber the Immunology Cluster of Excellence program of the JGU in which three disease-oriented and immunology-based collaborative research centers and one research training program are incorporated.

He was awarded the Georges-Köhler-Award of the German Society for Immunology in 2000. Starting August 2003, Dr. Schild is Chair of Immunology at the Johannes-Gutenberg University in Mainz, Germany.

Selected References (relevant to immunointervention)

  1. Herter, S., N. Hilf, Pr. Osterloh, G. Rechtsteiner, J. Höhfeld, H.G. Rammensee, and H. Schild. 2005. DALIS formation coincides with antigen presentation in influenza virus infected dendritic cells. J. Immunol. 175:891-898.
  2. Rechtsteiner, G., T. Warger, P. Osterloh, H. Schild*, and M.P. Radsak*. 2005. Priming of cytotoxic T lymphocytes by transcutaneus peptide immunization with imiquimod. J. Immunol. Cutting Edge 174:2476-2480. * joint senior authors
  3. Bopp, T., A. Palmetshofer, E. Serfling, V. Heib, S. Schmitt, C. Richter, M. Klein, H. Schild, E. Schmitt, and M. Stassen. 2005. NFATc2 and c3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by regulatory T cells. J. Exp. Med. 201:181187.
  4. Tenzer, S., B. Peters, S. Bulik, O. Schoor, C. Lemmel, M.M. Schatz, P.M. Kloetzel, H.G. Rammensee, H. Schild.* and H.G. Holzhütter. 2005. Modeling the MHC class-I pathway by combining predictions of proteasomal cleavage, TAP transport and MHC class-I binding. Cell. Mol. Life. Sci. 62:1025-1037.* corresponding author
  5. Tenzer, S., L. Stoltze, B. Schönfisch, J. Dengjel, M. Müller, S. Stevanovic, H.G. Rammensee, and H. Schild. 2004. Quantitative analysis of prion-protein degradation by constitutive and immuno-20S-proteasomes indicates differences correlated with disease susceptibility. J. Immunol. 172:1083-1091.
  6. Nussbaum, A.K., C. Kuttler, S. Tenzer, and H. Schild. 2003. Using the World Wide Web for the prediction of CTL epitopes. Curr. Opin. Immunol. 15:69-74.
  7. Seifert, U., C. Maranon, A. Shmueli, J.F. Desoutter, L. Wesoloski, K. Janek, P. Henklein, S. Diescher, M. Andrieu, H. de la Salle, T. Weinschenk, H. Schild, G. Hass, P. M. Kloetzel, X. Reiss, and A. Hosmalin. 2003. An essential role for Tripeptidypeptidase (TPPII) in the generation of MHC class I epitopes. Nat. Immunol. 4:375-379.
  8. Sun, Y., A.J.A.M. Sijts, M. Sing, K. Janek, A.K. Nussbaum, S. Kral, M. Schirle, S. Stevanovic, A. Paschen, H. Schild, P.M. Kloetzel, and D. Schadendorf. 2002. Expression of the proteasome activator PA28 rescues the presentation of a cytotoxic T lymphocyte epitope on melanoma cells. Cancer Research 62:2875-2882.
  9. Toes, R.E.M, A. K. Nussbaum, S. Degermann, M. Schirle, N. P. N. Emmerich, M. Kraft, C. Laplace, A. Zwinderman, T. P. Dick, J. Müller, B. Schönfisch, C. Schmid , H.-J. Fehling, S. Stevanovic, H. G. Rammensee, and H. Schild. 2001. Discrete cleavage motifs of constitutive and immunoproteasomes revealed by quantitative analysis of cleavage products. J. Exp. Med. 194:1-12.

Selected References (others)

  1. Wirtz, S., C. Becker, M.C. Fantini, E.E. Nieuwenhuis, I. Tubbe, P.R. Galle, H. Schild, M. Birkenbach, R.S. Blumberg, and M. Neurath. 2005. EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappaB activation. J. Immunol. 174:2814-24.
  2. Radsak, M., H. Salih, H.G. Rammensee, and H. Schild. TREM-1 in neutrophil inflammatory responses: Differential regulation of activation and survival. 2004. J. Immunol. 172:4956-63.
  3. Radsak., M., N. Hilf, H. Singh-Jasuja, S. Braedel, P. Brossart, H.G. Rammensee, and H. Schild. 2003. The Heat Shock Protein Gp96 binds to Human Neutrophils and Monocytes and stimulates effector functions. Blood 101:2810-5.
  4. Hilf, N., H. Singh-Jasuja, P. Schwarzmaier, C. Gouttefangeas, H.G. Rammensee, and H. Schild. 2002. Human Platelets Express Heat Shock Protein Receptors and Regulate Dendritic Cell Maturation . Blood 99:3676-3682.

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