Ruth Esther von Stebut, M.D.
Assistant Professor

Department of Dermatology
Johannes Gutenberg-University
Langenbeckstrasse 1
55131 Mainz

Portrait v. Stebut

Career history

Dr. von Stebut graduated in medicine in 1994 at the University of Lübeck. She was board certified in 2001 in Dermatology/Allergology after fellowships at the Department of Dermatology at the Charité, Berlin, and Mainz. Dr. von Stebut has gained considerable knowledge as senior physician in the diagnosis and treatment of cutaneous infectious diseases, autoimmune diseases and inflammatory disorders in the Dermatology Department of the University of Mainz. She has participated in several clinical trials translating basic research into clinical applications.

Dr. von Stebut received extensive training in cellular immunology with focus on dendritic cell biology during post-doctoral fellowships at the Dermatology Department of the Charité, Berlin, and at the Dermatology Branch, National Institutes of Health, Bethesda, USA. Between 1997/98 she completed graduate courses in Molecular and Cellular Mechanisms of Immunity and Cell Biology of Immunity and Inflammation at the Foundation of Advanced Education in Sciences, National Institutes of Health. Since 1999 her laboratory focuses on studying the role of dendritic cells for the induction of immune responses in allergic, autoimmune and infectious diseases.

Dr. von Stebut is frequent reviewer for several immunologically oriented high-impact journals (e.g. Blood, Journal of Immunology) and for national and international organisations (German Research Council (DFG), Pasteur Institute Paris, Society for Investigative Dermatology, Arbeitsgemeinschaft Dermatologische Forschung, European Society for Dermatologic Research). Dr. von Stebut has received several awards for outstanding accomplishments in research, including the Oscar-Gans-Award of the Deutsche Dermatologische Gesellschaft (2001) and the Egon Macher-Award of the Arbeitsgemeinschaft Dermatologische Forschung (2004).

Selected References (relevant to immunointervention)

  1. Belkaid, Y., von Stebut, E. , Mendez, S., Lira, R., Caler, E., Bertholet, S., Udey, M.C., and D. Sacks. 2002. CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major . J. Immunol. 168:3992-4000
  2. von Stebut, E., Belkaid, Y., Nguyen, B., Wilson, M., Sacks, D.L., and M.C. Udey. 2002. Skin-derived macrophages from Leishmania major-susceptible mice exhibit interleukin-12- and interferon-gamma-independent nitric oxide production and parasite killing after treatment with immunostimulatory DNA. J. Invest. Dermatol. 119:621-8
  3. von Stebut, E., Metz, M., Milon, G., Knop, J., and M. Maurer. 2003. Early macrophage influx to sites of cutaneous granuloma formation is dependent on MIP-1α/β released from neutrophils recruited by mast cell-derived TNFα. Blood 101:210-5
  4. von Stebut, E., Ehrchen, J.M., Belkaid, Y., Lopez Kostka, S., Mölle, K., Knop, J., Sunderkötter, C., and M.C. Udey. 2003. IL-1α promotes Th 1-differentiation and inhibits disease progression in Leishmania major-susceptible BALB/c mice. J. Exp. Med. 198:191-9
  5. Maurer, M., and E. von Stebut. 2004. Macrophage inflammatory protein-1. Int. J. Biochem. Cell Biol. 36:1882-6
  6. von Stebut, E., and M.C. Udey. 2004. Requirements for Th1-dependent immunity against infection with Leishmania major. Microb. Infect. 6:1102-9
  7. Zahn, S., Wirtz, S., Knop, J., Birkenbach, M., Blumberg, R.M., Neurath, M.F., and E. von Stebut. 2005. Impaired Th1 responses in Epstein-Barr virus-induced gene (EBI) 3-deficient mice challenged with physiological doses of Leishmania major. Eur. J. Immunol. 35:1106-12.

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