Univ.-Prof. Dr. ANDREAS HILDEBRANDT

Wissenschaftlicher Werdegang

April 2011
Berufung zum Universitätsprofessor auf Lebenszeit für Software-Technik und Bioinformatik an die Johannes Gutenberg-Universität Mainz (JGU)

2009
Auszeichnung mit dem "Best poster award" der German Conference on Bioinformatics 2009

2007
2. Preis des "Best paper award" der 5. European Conference on Computational Biology

2005
Open Source-Sonderpreis des doIt Software-Award für die BALL-Bibliothek

April-Juni 2005
Wissenschaftlicher Assistent am Center for Bioinformatics an der Universität des Saarlandes in Saarbrücken

April 2005
Promotion (summa cum laude) an der Universität des Saarlandes in Saarbrücken
Titel der Dissertation: "Biomolecules in a structured solvent - A novel formulation of nonlocal electrostatics and its numerical solution"

2002 - März 2005
Wissenschaftlicher Assistent am Max-Planck-Institut für Informatik in Saarbrücken

2002-2005
PhD-Studium der Bioinformatik am Zentrum für Bioinformatik der Universität des Saarlandes in Saarbrücken

2002
Diplom im Fach Informatik an der Universität des Saarlandes in Saarbrücken

1999-2002
Beteiligung an verschiedenen Forschungsprojekten der Arbeitsgruppe Theoretische Physik an der Universität des Saarlandes in Saarbrücken

1997-2002
Studium der Physik und Informatik an der Universität des Saarlandes in Saarbrücken

Lehr- und Forschungsschwerpunkte

• Strukturbasierte Bioinformatik
• Transkriptom- und Proteomanalyse
• Computergestützter Wirkstoffentwurf
• Medizinische Bioinformatik
• Programmpakete BALL/BALLView und OpenMS
• Theoretische Biophysik und Physik im Bereich der Bioinformatik

Publikationen (Auswahl)

• Benz, F, Hildebrandt, A, and Hack, S (2012). A Dynamic Program Analysis to find Floating-Point Accuracy Problems. In: PLDI '12: Proceedings of the 2012 ACM SIGPLAN Conference on Programming Language Design and Implementation.
• Dietzen, M, Zotenko, E, Hildebrandt, A, and Lengauer, T (2012). On the applicability of elastic network normal modes in small-molecule docking. J Chem Inf Model, 52(3):844-56.
• Bardhan, JP and Hildebrandt, A (2011). A Fast Solver for Nonlocal Electrostatic Theory in Biomolecular Science and Engineering. In: Design Automation Conference (DAC), 2011 48th ACM/EDAC/IEEE.
• Dehof, AK, Rurainski, A, Bui, QB, Böcker, S, Lenhof, H, and Hildebrandt, A (2011). Automated bond order assignment as an optimization problem. Bioinformatics, 27(5):619-625.
• Kneissl, B, Müller, SC, Tautermann, CS, and Hildebrandt, A (2011). String Kernels and High-Quality Data Set for Improved Prediction of Kinked Helices in α-Helical Membrane Proteins. Journal of Chemical Information and Modeling, 51(11):3017-3025.
• Hildebrandt, A, Dehof, A, Rurainski, A, Bertsch, A, Schumann, M, Toussaint, NC, Moll, A, Stockel, D, Nickels, S, Müller, SC, Lenhof, HP, and Kohlbacher, O (2010). BALL - Biochemical Algorithms Library 1.3. BMC Bioinformatics, 11(1):531.
• Singh, KK, Erkelenz, S, Rattay, S, Dehof, AK, Hildebrandt, A, Schulze-Osthoff, K, Schaal, H, and Schwerk, C (2010). Human SAP18 mediates assembly of a splicing regulatory multiprotein complex via its ubiquitin-like fold. RNA.
• Hussong, R, Gregorius, B, Tholey, A, and Hildebrandt, A (2009). Highly accelerated feature detection in proteomics data sets using modern graphics processing units. Bioinformatics, 25:1937-1943.
• Kneissl, B, Leonhardt, B, Hildebrandt, A, and Tautermann, CS (2009). Revisiting Automated G-Protein Coupled Receptor Modeling: The Benefit of Additional Template Structures for a Neurokinin-1 Receptor Model. Journal of Medicinal Chemistry, 52(10):3166-3173.
• Sturm, M, Bertsch, A, Gröpl, C, Hildebrandt, A, Hussong, R, Lange, E, Pfeifer, N, Schulz-Trieglaff, O, Zerck, A, Reinert, K, and Kohlbacher, O (2008). OpenMS - An open-source software framework for mass spectrometry. BMC Bioinformatics 2008, 9(163).
• Zhang, F, Skoda, MW, Jacobs, RM, Zorn, S, Martin, RA, Martin, CM, Clark, GF, Weggler, S, Hildebrandt, A, Kohlbacher, O, and Schreiber, F (2008). Reentrant Condensation of Proteins in Solution Induced by Multivalent Counterions. Physical Review Letters, 101(14):148101.
• Hildebrandt, A, Blossey, R, Rjasanow, S, Kohlbacher, O, and Lenhof, H (2007). Electrostatic potentials of proteins in water: a structured continuum approach. Bioinformatics, 23(2):e99-103.
• Hussong, R, Tholey, A, and Hildebrandt, A (2007). Efficient Analysis of Mass Spectrometry Data Using the Isotope Wavelet In: COMPLIFE 2007: The Third International Symposium on Computational Life Science, pp. 139-49, American Institute of Physics (AIP) Proceedings Volume 940.
• Schulz-Trieglaff, O, Hussong, R, Gröpl, C, Hildebrandt, A, and Reinert, K (2007). A Fast and Accurate Algorithm for the Quantification of Peptides from Mass Spectrometry Data In: Proceedings of the Eleventh Annual International Conference on Research in Computational Molecular Biology (RECOMB 2007), Lecture Notes in Bioinformatics (LNBI) 4453, pp. 473–87, Springer. Lecture Notes in Bioinformatics.
• Lange, E, Gröpl, C, Reinert, K, Kohlbacher, O, and Hildebrandt, A (2006). High-Accuracy Peak Picking of Proteomics Data using Wavelet Techniques In: Proceedings of the Pacific Symposium on Biocomputing (PSB 2006).
• Moll, A, Hildebrandt, A, Lenhof, H, and Kohlbacher, O (2006). BALLView: An object-oriented molecular visualization and modeling framework. J. Comput.-Aided Mol. Des., 19(11):791.
• Toll, H, Berger, P, Hofmann, A, Hildebrandt, A, Oberacher, H, Lenhof, HP, and Huber, CG (2006). Glycosylation patterns of human chorionic gonadotropin revealed by liquid chromatography-mass spectrometry and bioinformatics. Electrophoresis, 27(13):2734-2746.
• Comtesse, N, Zippel, A, Walle, S, Monz, D, Backes, C, Fischer, U, Mayer, J, Ludwig, N, Hildebrandt, A, Keller, A, Steudel, W, Lenhof, H, and Meese, E (2005). Complex humoral immune response against a benign tumor: frequent antibody response against specific antigens as diagnostic targets. Proc Natl Acad Sci USA, 102(27):9601-6.
• Hildebrandt, A, Blossey, R, Rjasanow, S, Kohlbacher, O, and Lenhof, H (2004). Novel formulation of nonlocal electrostatics. Phys. Rev. Lett., 93:108104.